PDL-1 cpd 10

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PD-L1-IN-1 是一种有效的 PD-L1 抑制剂，IC50 为 115 nM。PD-L1-IN-1与PD-L1蛋白强结合，并在表达 PD-L1 的癌细胞（PC9 和 HCC827 细胞）和外周血单核细胞的共同培养中激发 PD-L1 蛋白，增强后者的抗肿瘤免疫活性。PD-L1-IN-1 显著增加了干扰素 γ 的释放和癌细胞的凋亡诱导，对健康细胞的细胞毒性较低。

PD-L1-IN-1 is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells (PC9 and HCC827 cells) and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly increased interferon γ release and apoptotic induction of cancer cells, with low cytotoxicity in healthy cells.

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Immunology/Inflammation

PD-1/PD-L1

PD-1/PD-L1

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2767424-13-3

377.44

C21H23N5O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (331.18 mM; 超声助溶 (<60°C)

CC1=C(C=CC=C1COC=2N=C(NCCNC(C)=O)N=CN2)C3=CC=CC=C3

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(-20℃)

With Ice Pack

≥ 2 years